Proton Pump
The proton pump is an integral membrane protein that is capable of moving protons across a biological membrane. Mechanisms are based on conformational changes of the protein structure or on the Q cycle. In cell respiration, the proton pump uses energy to transport protons from the matrix of the mitochondrion to the inter-membrane space. The proton pump does not create energy, but forms a gradient that stores energy for later use.
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Tenatoprazole是质子泵抑制剂(PPI)的前体药物，抑制质子转运， IC50为3.2 μM。
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FTI-277盐酸盐是法尼基转移酶FTase抑制剂，高效Ras CAAX肽模拟物，可抑制H-Ras和K-Ras信号转导。
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Omeprazole (奥美拉唑; Prilosec) 是质子泵抑制剂，可作用于消化不良。
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LB42708 是一种口服有效的 farnesyltransferase (FTase) 抑制剂。
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PF 03716556 is a potent, and selective acid pump (H+,K+ ATPase)antagonist, with pIC50 value of 6.009.
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